Seems like nothing runs in Vista at the moment
, and who knows when Belkin will get around to releasing drivers for it. I don't know how well it'd work in compatibility mode, but that's a possibility.
If you opt to go with traditional cooling through air-movement, SilverStone has an unorthodox case that flips the motherboard. The processor sets in a tunnel that has an intake fan and an exhaust fan. Combined with a quality cpu cooler, it's possibly the best air cooling case out there. Best of all, it doesn't come with a high price tag. The model is SilverStone TJ-06 Wind Tunnel; can usually find it for around $130.
For the graphics card, you can invest a little chunk and get the EVGA GeForce 8800GTS 320MB; it'll set you back around $300 or so, but it should do a great job for you. I also believe that it's Vista compatible, but don't hold me to it.