The new dslrs handle high iso very very well with minimal noise. I also had to take night shots of the conditions of the homeless at 2 am in the morn. Definitely couldnt use flash. but with a 50 1.4 and near dark conditions the cam worked well enough to capture the mood..=)
For me the story is much more important by how sharp the shot is. A slightly blurred shot with something to say is a much better than a tack sharp shot with nothing to say. JMHO..=)